Although all IAV proteins, including HA, NA, NP, and RNA polymerases, are potential targets for developing anti-influenza therapeutic drugs, the most effective anti-influenza therapeutic candidates to date have been viral M2 ion channel (e.g., amantadine and rimantadine) and NA (e.g., Oseltamivir, zanamivir, and peramivir) inhibitors. This evidence concerns the gene XK and influenza.