Most members of the TNFRSF family are involved in apoptosis regulation and activation of inflammation via NF-κB activation; TNFRSF3 and 6 may induce apoptosis as well as activate the immune response by increasing secretion of inflammatory cytokines including IL-8 as well as induce apoptosis of tumor cells (44, 45). Here, LTBR is linked to neoplasm.