CR2 and neoplasm: Concerning ORR, an increase in the frequency of CD21- B-cells was not significantly associated with response rate in the univariable model (OR=0.18, 95%CI=0.03-1.09, p=0.061), while it was a significant negative predictor for response when adjusted for tumor entity (OR=0.09, 95%CI=0.01-0.96, p=0.046) (Table 3 and Figure 3).