At baseline, there was no significant association, neither with DCR nor ORR of total B-cell, CD21- B-cells, unswitched memory B-cells, transitional zone B-cells, naïve B-cells, switched memory B-cells, CD24+CD38++ regulatory B-cells and plasmablasts measurements in both, univariable logistic regression models, as well as in the multivariable analysis adjusted for tumor entity (Table 2). This evidence concerns the gene CR2 and neoplasm.