NFKB1 and neoplasm: Transcription factors (TFs) (Nuclear factor-κB (NF-κB), STAT1/STAT3, HIFs, AP-1, and Nrf2) orchestrators various inflammation-related signaling pathways to modulate the inflammatory response, through inflammatory mediators (such as cytokines, chemokines) and immune cells infiltration (tumor-associated macrophages), thus promoting tumorigenesis.