After adjustment for pre-ART CD4+ T cell counts, viral load, smear grade, and the time between ATT and ART, we found that baseline frequencies of CXCR3+ naïve CD8+ T cells were independently associated with a lower odds ratio of TB-IRIS development (OR, 0.885 [95% CI (0.795 – 0.985)]). Here, CD4 is linked to tuberculosis.