More specifically, one could hypothesize that Mtb- harboring cells, more predominant in TB-IRIS patients at IRIS onset, could produce higher amounts of CXCR3+ ligands (ie. CXCL9, C XCL10, CXCL-11), therefore increasing the trafficking of CXCR3+ CD8+ T cells into sites of inflammation. The gene discussed is CXCR3; the disease is tuberculosis.