Additionally, by applying the same model to the frequencies of CXCR3+ memory CD8+ T cells at timepoint 1, we noted that increased frequencies of CXCR3+ naïve CD8+ T cells were associated with reduced risk of TB-IRIS development (OR, 0.860 [95% CI (0.758 – 0.976)]). The gene discussed is CXCR3; the disease is tuberculosis.