CD8A and neoplasm: have used IMC to study TILs within non-small cell lung cancer samples and identified a new burned-out CD8+ TIL subset (Ebo) that was especially accumulated within the TME and was a highly proliferative, overactivated, and apoptotic dysfunctional CD8+ tumor-infiltrating subpopulation that produced low amount of INFγ, functionally distinct from exhausted T cells.