investigated for the prognostic significance of the TME composition analyzed using IMC in high-grade serous ovarian cancer and pointed some features associated with a long term survival (high levels of granzymeB+ CD8+ T cells, CD11b+Vista+ cells and interactions between granzymeB+ CD8+ T cells and Vista-CD4+ T cells; low levels of CD196+, CD45RO+ and CD73+ cells and poor interactions between CD73+ cells and Vista-CD4+ T cells, macrophages and B-cells) (22, 52). Here, CD4 is linked to ovarian serous adenocarcinoma.