CD4 and colorectal cancer: identified a special regulatory T cell–like subpopulation with an expression of lymphocyte activation gene 3 (LAG3+ T cells) in classic-Hodgkin Lymphoma, which was not find in normal reactive lymph nodes (23).Thanks to IMC, abnormal EpCAM+ PD-L1+ CD4+ T cells have been discovered in patients with colorectal cancer by Zhang et al.