CDH11 and neoplasm: also used pancreas cancer xenograft in CDH11 deficient and wild-type mice models to demonstrate using IMC that the inhibition of CDH11, expressed by cancer-associated fibroblasts, caused a reduction in tumor growth, increased the tumor response to gemcitabine and was implicated in immunosuppression and extracellular matrix deposits consisting the highly fibrotic stroma of pancreatic ductal adenocarcinoma (57).