CD8A and breast cancer: has pointed the role of MNK1/2-eIF4E axis in the metastatic spreading of post-partum breast cancers and they subsequently used IMC to confirm the presence of high-levels of phospho-eIF4E high-expressing tumor cells and CD8+ T cells with activated dysfunctional phenotype markers in samples of humans with this particular clinical presentation of aggressive breast cancer pointing in this manner a potential new therapeutic target in this field (61).