HLA-DR4 association with ICI-associated diabetes in patients with a variety of cancers treated with anti-PD-1/PD-L1 (42).HLA-DR4 association with ICI-associated diabetes in patients treated with anti-PD-1/PD-L1 (43).HLA-DRB1*04:05 association with ICI-induced arthritis in patients with a variety of cancers (69).HLA-DRB1*11:01 association with ICI-induced pruritis and HLA-DQB1* 03:01 and colitis in patients with non-small lung cancer (NSCLC) or melanoma treated with anti-PD-1, anti-CTLA-4 or their combination (71). This evidence concerns the gene CTLA4 and arthritic joint disease.