Thyroid autoantibodies (anti-TPO, anti-tg) at baseline increases the risk of thyroid dysfunction in patients treated with nivolumab or pembrolizumab (85–87, 109).Baseline autoantibody signatures, such as those targeting TNF-α signaling pathways may be predictive of irAEs in patients with melanoma treated with anti-CTLA-4, anti-PD-1 or their combination (110).Skin irAEs may be more frequent in patients with positive RF at baseline in patients with NSCLC treated with nivolumab or pembrolizumab (87). This evidence concerns the gene TPO and non-small cell lung carcinoma.