Moreover, it may elevate other proinflammatory cytokines, including IL-6, IL-8 and IL-10, generated by other bystander immune cells, resulting in even more severe hyperactive immune disorders, hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) (45). The gene discussed is CXCL8; the disease is hemophagocytic syndrome.