In a BRAFV600; PTEN KO mouse melanoma model in which eIF4E cannot be phosphorylated (eIF4EKI), they showed an increase in the secretion of many cytokines linked with the expansion, recruitment (such as CCL2, CCL12, and CCL5), and function (such as MMP-9) of immunosuppressive cells such as MDSCs. The gene discussed is PTEN; the disease is melanoma.