Based on the survival information from the TCGA database, we found that two (LGG and LIHC) of pan-cancer showed a highly consistent relationship between poor prognosis and high METTL1 expression; METTL1 expression in ACC, KIRC, and MESO is significantly related to OS, PFS, and DSS, instead of DFS. The gene discussed is METTL1; the disease is cancer.