NCK1 and psoriasis: Interestingly, Nck main function is closely related to the regulation of actin cytoskeleton remodeling and so far, the role of TCR-regulated actomyosin contractile networks in Tγδ17 differentiation or effector function has not been addressed, although actomyosin cytoskeleton reorganization is required for Tγδ17 and Th17 migration to the inflamed site in the IMQ model of psoriasis (54).