Inhibiting EphA2 prevented transmigration of C. neoformans (100), and a similar dependence on EphA2 has been observed for CNS entry by several other pathogens including Chlamydia trachomatis, Epstein-Barr virus, and malaria parasites (101–103), indicating that ephA2 may generally be involved with BBB permeability and pathogen entry (104). This evidence concerns the gene EPHA2 and malaria.