CXCL8 and pancreatic neoplasm: used radiation therapy to induce tumor secretion of IL-8 (CXCL8), and found that CD70-CAR-engineered T cells expressing either of the IL-8 receptors CXCR1 or CXCR2, showed enhanced migration and persistence, leading to complete tumor regression and immunologic memory in models of aggressive tumors, including glioblastoma, ovarian, and pancreatic cancers (176).