Furthermore, three major points depicting the interplay between HIV infection and IFN-I are of particular interest, viz., (i) the sensitivity of HIV-1 isolates to IFN-I inhibition consistently changes over time, (ii) HIV-1 isolates obtained during ART therapy were relatively IFN-I sensitive, and (iii) the viruses that rebounded after treatment interruption displayed the highest degree of IFNα2 and IFNβ resistance. Here, IFNB1 is linked to HIV infectious disease.