For instance, a 45-week monthly treatment on COPD patients via intravenously infusing canakinumab, a human anti-IL-1b monoclonal antibody, did not show statistical difference in forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) between treatment and placebo groups (Rogliani et al., 2015). Here, IL1B is linked to chronic obstructive pulmonary disease.