For example, marker genes for disseminated intravascular coagulation, such as those encoding coagulation factor VIII, and genes encoding leukotrienes, prostaglandins, and cyclooxygenase (i.e., cox2), all of which are considered markers of the acute phase of the disease (Peters-Golden et al., 2005; Gómez-Abellán and Sepulcre, 2016; Wang et al., 2016). Here, PTGS2 is linked to Disseminated intravascular coagulation.