In placental tissues of IUGR twins, altered DNA methylation status (with differences larger than 10% compared to healthy control twins) were identified in DMRs that overlapped the promoters of 8 genes that are known to be important for lipid metabolism and neural development, including DECR1, ZNF300, DNAJA4, CCL28, LEPR, HSPA1A/L, GSTO1, and GNE (94). This evidence concerns the gene GSTO1 and fetal growth restriction.