Similarly, administration of an insulin receptor antagonist S961 induced acute, severe insulin resistance in C57BL6/J mice (79), which was accompanied by increased SA-β-Gal+ cells and increased mRNA levels of aging and SASP-related genes including p16INK4a, p21Cip1, and Bambi in islets (39, 70). Here, CDKN2A is linked to Insulin resistance.