GNG7 is a gene located on chromosome 19 codifying for the γ7 subunit of guanin-binding G proteins, which is involved in contact-mediated cell growth blockade and acts as an oncosuppressor (31), whose promoter methylation has been found in many cases of head/neck cancer and associated with higher tumor volume and lesser metastatic potential (31). This evidence concerns the gene GNG7 and head and neck cancer.