Another lncRNA, called C5orf66-AS1, regulates several genes, including PAQR7, a progesterone receptor that causes a progesterone A-B receptor-independent reduction in GnRH, whose expression has been found to have a role in progression and invasion of null-cell pituitary adenomas (24, 29). This evidence concerns the gene PAQR7 and pituitary gland adenoma.