Its full function is still unknown, although some evidence suggests it could bind the Sp1 transcriptional factor, which has several regulatory functions (i.e., cell cycle, apoptosis, etc.)including an interaction with AHR favoring the ubiquitination and consequent degradation of the estrogenic receptor α (ERα) in murine breast and uterine cancer (30). The gene discussed is AHR; the disease is uterine cancer.