Compared with non-T2DM controls, patients with T2DM had significantly lower levels of LH (P<0.001), FSH (P<0.001) and E2 (P<0.001); no difference in the testosterone level between patients with T2DM and non-T2DM controls was observed (P=0.421; Table 1). This evidence concerns the gene PLOD1 and type 2 diabetes mellitus.