According to our study, the LH and FSH levels began to increase obviously approximately from 45 years old, indicating the beginning of perimenopausal stage, which commonly lasts 2 to 10 years and is characterized by less regular menstruation (69); the relations between gonadotropins and LDL-C and TC were found in female patients with T2DM aged between 51 and 60, generally a perimenopausal or early postmenopausal state. The gene discussed is PLOD1; the disease is type 2 diabetes mellitus.