We also found that LDL-C and TC levels were positively correlated with LH and FSH, and negatively correlated E2 with LDL-C and TC levels in patients with T2DM aged between 51 and 60, suggesting perimenopausal changes of gonadotropins and E2 are correlated with dyslipidemia. The gene discussed is PLOD1; the disease is type 2 diabetes mellitus.