HMGCS2 and type 1 diabetes mellitus: The qRT-PCR results (Figure 5C) showed that in T1DM rats, the mRNA expression levels of Idi1, Acsl3, Coasy, Oxct1, Bdh1, and Mpv17l were significantly down-regulated, and the expression of Fads2 and Hmgcs2 were significantly up-regulated at specific time points.