After the onset of ischemic stroke, upon activation, γδ T cells can release IL-17a, IL-21, IL-22, and IFN-γ, and then participated in the pathogenic process, including secretion of pro-inflammatory factors, breakdown of the integrity of BBB, and recruitment of inflammatory cells into the affected tissues, and eventually cause irreversible brain injury. This evidence concerns the gene IL22 and ischemic stroke.