Mechanistically, RSV could ameliorate NAFLD and hepatic steatosis in obese mice by promoting the SIRT1/AMPK pathway (Tian et al., 2016), possibly mediated by activating SIRT11 as a Sirt1 enhancer (Zhang et al., 2018), and ameliorating the accumulation of LDs by mediating a SIRT1/ATF6-dependent mechanism (Zhou et al., 2018). Here, ATF6 is linked to metabolic dysfunction-associated steatotic liver disease.