Consistent with the association of a decrease in Cx46 phosphorylation and cataracts, the absence PKCγ in a knockout mice was correlated with the development of cataracts and an increase of oxidative stress, suggesting that the lack of Cx46 regulation may disrupt channel function and make the cells prone to damage by oxidative stress (Lin et al., 2006). The gene discussed is PRKCG; the disease is cataract.