It has been reported that Cx46 in the lens interacts with Ca2+-calmodulin (CaM) and that a Cx46 mutant (G143R) associated with cataracts in humans enhances the Cx46-CaM interaction and forms gap junction channels and hemichannels with altered voltage gating and permeability (Hu et al., 2018). Here, GJA3 is linked to cataract.