Due to the importance of Cx46 (a connexin isoform) in lens physiology (Jiang, 2010; Berthoud and Ngezahayo, 2017; Bai et al., 2021), and the recent discovery of its importance in cancer (Banerjee et al., 2010; Burr et al., 2011; Mulkearns-Hubert et al., 2019; Acuña et al., 2020; Acuña et al., 2021; Orellana et al., 2021), our group have been interested in the posttranslational regulation of this protein, and this review focuses on how Cx46 posttranslational regulation affects lens cells’ functions. The gene discussed is GJA3; the disease is cancer.