Additionally, in a mice model of high fat-induced obesity, MO fermented extracts demonstrated its efficacy in reducing hepatic lipid accumulation by causing downregulation of lipogenic genes (ACC, FAS, C/ENPα, SREBP1c, LPL), lipid oxidative genes [CD36, ACOX1, CPT1 (NFM), HSL], and oxidative stress genes (UCP2 and UCP3). The gene discussed is NEFM; the disease is obesity due to melanocortin 4 receptor deficiency.