EGFR and non-small cell lung carcinoma: In addition, 12%–34% of NSCLC patients with EGFR mutations have uncommon mutations (Yang et al., 2015; Castellanos et al., 2017; Robichaux et al., 2018), which include exon 20 insertion, exon 18 G791X, exon 20 S768I, and exon 21 L861Q mutations.