Our previous multi-center, double-blind, placebo-controlled clinical trial (CATLA study) confirmed that the addition of CHM (Yiqi-Yangyin-Jiedu decoction, YYJD) to EGFR-TKI (gefitinib, erlotinib, or icotinib) significantly prolongs progression-free survival (PFS) and improves the quality of life (QoL) in NSCLC patients (Jiao et al., 2019). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.