AKT1 and allergic asthma: extracts can regulate the AMPK/PI3K/AKT/p38-NF-κB and TGF-β/Smad/Bcl2/caspase/LC3 signaling pathways to produce cascade reaction and activate macrophages, thus alleviating allergic asthma and lung infection induced by OVA (Tirpude et al., 2021).