• ↑** ratio of CD4 (+), CD25 (+), Foxp3 (+) and Treg cells to CD4 (+), CD25 (-) effector T cells collected from the splenic, thymic, and peripheral blood cells in LZ-SMS-treated moderate and severe SLE mice increased significantly compared with the untreated PBS group. This evidence concerns the gene CD4 and systemic lupus erythematosus.