SYK and systemic lupus erythematosus: This is an important finding considering celastrol can downregulate the signaling cascade of the SYK-MEK-ERK-NFkB (Yu et al., 2015), and the downregulation of IL-12 p40 (which correlates negatively with lupus SLE activity), which ultimately contributes to excessive IL-10 (positively correlated with lupus pathology) (Liu et al., 1999).