Liao et al. examined the effect of ICT on human SLE peripheral blood mononuclear cells (PBMC) and MRL/lpr mice and found that this extract inhibited CD4 (+) T cell overactivity, promoted FoxP3-IL17a balance, and enhanced Treg cell suppression (Liao et al., 2016). Here, FOXP3 is linked to systemic lupus erythematosus.