IL1B and atherosclerosis: Although Tongxinluo only inhibits the expression of IL-1β in vascular plaques and does not significantly reduce its concentration in serum, in patients with atherosclerosis, IL-1β is mainly located in the vascular plaques (Galea et al., 1996), so, it can also be partially proved that Tongxinluo plays an important role in inhibiting atherosclerotic inflammation.