Other TCMs, such as Wuweiwan (WMW Meiwan, WMW), reduce CAC (colitis and colorectal cancer) by regulating the balance between “tumour promoting bacteria” and “carcinoma suppressing bacteria” and the NF-kB/IL-6/STAT3 pathways (Jiang et al., 2020). Here, STAT3 is linked to carcinoma.