Figure 3E shows that for SCLC (George et al.), the type and mutation frequency of the driver genes in the top 20 mutation frequencies in the cohort. The results showed that there was no significant difference between the driver genes in the top 20 mutation frequencies of MMP9-High and MMP9-Low. In SCLC (Jiang et al.), the mutation frequency of MMP9-High is significantly higher than that of MMP9-Low in PTPRB and NTRK (Figure 3F). Supplementary Figures S1A,B shows the mutual exclusion and co-occurrence of the top 20 driving mutations in MMP9-High and MMP9-Low, respectively. The gene discussed is PTPRB; the disease is small cell lung carcinoma.