CD40 and neoplasm: Intratumoral delivery of the cytokine interleukin-2, had little effect by itself (Jackaman et al., 2003) but when combined with anti-CD40, caused local regression and, importantly regression of a distal untreated tumor (Jackaman et al., 2012), possibly due to the induction of inflammation within the tumor (Jackaman et al., 2008).