CD274 and diabetes mellitus: Regarding ICI-DM, the data shows that the shortest median TTO was 50 (IQR 31–100) days for anti-CTLA-4, the longest was 89 (IQR 30–228.5) days for anti-PD-1, and the median onset time was 63(IQR 30–169) days for anti-PD-L1.