CD4 and colitis: Differences in the association between different ICIs and pancreatic AEs may be related to modulation of different T-cell colonies and cytokines, as previous studies have demonstrated that anti-PD-1 diabetes is associated with the predominance of exhausted CD8 cells producing IFN-γ expression, whereas anti–CTLA-4 colitis has demonstrated the predominance of CD4 cells and tumor necrosis factor-alpha expression (Reese et al., 2020; Mourad et al., 2021).