CD274 and hypopituitarism: For example, gastrointestinal (colitis) and endocrine toxicity (hypophysitis, adrenal insufficiency, hypopituitarism) were more preferentially reported with anti-CTLA-4, whereas thyroid dysfunction, pneumonitis and myocarditis were more frequently recorded with anti-PD-1/PD-L1 (Raschi et al., 2020).