On the other hand, the development of diet-induced obesity was prevented by treating Sprague Dawley rats when the Mas receptor was stimulated with oral Ang (1–7), or in transgenic rats overexpressing Ang (1–7) (Santos et al., 2014; Blanke et al., 2015; Schuchard et al., 2015). The gene discussed is ANGPT1; the disease is obesity due to melanocortin 4 receptor deficiency.