Mahalakshmi et al. (2020) elucidated the benefits of exercise on PD, and irisin was a mediator of exercise-induced BDNF. Raefsky and Mattson (2017) suggested that irisin might protect neuronal mitochondria function in PD via antioxidation, autophagy, and DNA repair regulations. This evidence concerns the gene FNDC5 and Parkinson disease.