Mahalakshmi et al. (2020) elucidated the benefits of exercise on PD, and irisin was a mediator of exercise-induced BDNF. Raefsky and Mattson (2017) suggested that irisin might protect neuronal mitochondria function in PD via antioxidation, autophagy, and DNA repair regulations. Here, BDNF is linked to Parkinson disease.