Studies have reported increased levels of MMPs such as MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, and MT1-MMP, in AD, as well as their neuroprotective effect and Aβ cleavage properties in the animal model of AD (Fragkouli et al., 2014; Kaminari et al., 2017). This evidence concerns the gene MMP2 and Alzheimer disease.