In line with this, Senescence-Associated Secretory Phenotype (SASP) biomarkers, which is upstream of JAK/STAT signaling at the cellular level, has been reported to be elevated in the plasma of older adults with MCI, MCI + Major Depressive Disorder (MDD), and MDD (Diniz et al., 2021). The gene discussed is SOAT1; the disease is major depressive disorder.