For example, various missense mutations in the small heat shock protein 27 (Hsp27) cause the neuropathies Charcot-Marie-Tooth Disease Axonal Type 2F (CMT2F) and Distal Hereditary Motor Neuropathy 2B (dHMN2B; Houlden et al., 2008; Tanabe et al., 2018). The gene discussed is HSPB3; the disease is neuropathy.