Similarly, the activation of Rac1 observed after AUTS2 overexpression in N1E-115 mouse neuroblastoma cells (the “AUTS2-Rac1 pathway”) may also be explained, at least in part, by AUTS2 regulation of transcripts Prex1 and Rasgrf2, which were significantly reduced in Auts2del15/del15 neocortex. This evidence concerns the gene RAC1 and neuroblastoma.