For example, mouse models of microcephaly associated CDK5RAP2 disease requires a complete knockout of CDK5RAP2 and result in apoptosis as the primary cause of neuronal progenitor cell depletion and microcephaly (Barrera et al., 2010; Buchman et al., 2010; Lizarraga et al., 2010). Here, CDK5RAP2 is linked to microcephaly.