Cantagrel et al. (2004) first reported the gene in two males with intellectual disability. However, very little is known about nexmif. Previous studies reported that nexmif mRNA was strongly expressed in the cortex, hippocampus, cerebellum, and olfactory bulb (Allen Institute for Brain Science, 2004; Cantagrel et al., 2009). At the protein level, nexmif is specifically distributed in post-mitotic neuron nuclei but not in glia. Strong protein expression is also detected from the E17 developmental stage through adulthood in mice (Gilbert and Man, 2016). The gene discussed is NEXMIF; the disease is Intellectual disability.