To explore the mechanism underlying the protective effect of MCC950 in METH-induced cerebellar degeneration, we conducted an immunoblotting analysis of NLRP3 pathway proteins including NLRP3, ASC, Caspase-1, Cleaved Caspase-1 (P20), IL-1β and mature IL-1β. The gene discussed is CASP1; the disease is cerebellar degeneration.