NLRP3 and cerebellar degeneration: To explore the mechanism underlying the protective effect of MCC950 in METH-induced cerebellar degeneration, we conducted an immunoblotting analysis of NLRP3 pathway proteins including NLRP3, ASC, Caspase-1, Cleaved Caspase-1 (P20), IL-1β and mature IL-1β.