Given that mature IL-1β secretion has been shown to be a key mediator in inflammation-induced neuronal apoptosis in neurodegenerative disease (Rui et al., 2021), our mechanistic finding suggests that pharmacological inhibition of NLRP3 may alleviate inflammation through Caspase 1 dependent mature IL-1β secretion (Figure 6). Here, CASP1 is linked to neurodegenerative disease.