APC and brain injury: Previous studies indicated that 3K3A-APC is protective in rodent models of large artery infarcts (Guo et al., 2009a; Wang et al., 2012, 2013; Sinha et al., 2018), white matter stroke (Huuskonen et al., 2022), traumatic brain injury (Walker et al., 2010), ALS (Zhong, 2009; Shi et al., 2019), and AD (Lazic et al., 2019).