The present findings in pericyte-deficient mice are consistent with 3K3A-APC’s direct vasculoprotective and neuronal protective effects (Griffin et al., 2015, 2018; Amar et al., 2018) as previously shown in rodent models of stroke (Guo et al., 2009a; Wang et al., 2012, 2013; Sinha et al., 2018; Huuskonen et al., 2022), traumatic brain injury (Walker et al., 2010), ALS (Zhong, 2009; Shi et al., 2019), and AD (Lazic et al., 2019). Here, APC is linked to amyotrophic lateral sclerosis.