In addition to ischemia, it is also possible that considerably greater fluxes of blood-derived toxic fibrinogen in Pdgfrb + ⁣/− compared to Pdgfrb+/+ mice may present an extra challenge on already reduced pericyte capability to address the elevated fibrinogen burden, which has been shown to lead to autophagy-mediated pericyte cell death in another pericyte-deficient PdgfrbF7/F7 mouse line with 7 point mutations in the Pdgfrb gene causing impaired PDGFRβ signaling and in cultured mouse pericytes when challenged with fibrinogen in vitro (Montagne et al., 2018). This evidence concerns the gene PDGFRB and ischemia.