Given the importance of RPE function for photoreceptor health, and roles for SARM1 in non-neuronal cells (Strauss, 2005; Panneerselvam et al., 2013; Carty et al., 2019) we were interested to examine the effect of SARM1 deficiency on the RPE in a model of retinal degeneration that is thought to initiate with RPE loss. The gene discussed is SARM1; the disease is retinal degeneration.