SARM1 activation has been implicated in a range of models of pathological neurodegeneration, including amyotrophic lateral sclerosis (ALS; White et al., 2019), traumatic brain injury (Marion et al., 2019), and chemotherapy induced peripheral neuropathy (Geisler et al., 2016; Bosanac et al., 2021). The gene discussed is SARM1; the disease is amyotrophic lateral sclerosis.