Through repeated comparison, we found that several cytokines, including IL-1 (interleukin-1), IL-6 (interleukin-6), TNF-α (tumor necrosis factor-α), and IFN-γ (interferon-γ), always coexist and are critical to CRS caused by infection or immunotherapy [35]. This evidence concerns the gene IL1B and congenital rubella syndrome.