Wang et al. [13, 23] presented that B cell-activating factor was crucial to promote B cell survival in ectopic lymphoid tissues in nasal polyps, suggesting that BAFF was involved in the physiopathologic mechanism of CRSwNP and might serve as an objective biomarker for its individualized treatment. The gene discussed is TNFSF13B; the disease is chronic rhinosinusitis with nasal polyps.