VWF and aortic valve insufficiency: As VWF has diverse functions, laboratory testing for VWD and other VWF-related disorders (i.e., thrombotic thrombocytopenic purpura [8] or a variety of cardiac lesions that result in clearance of larger multimers, such as aortic regurgitation, mitral insufficiency, and hypertrophic cardiomyopathy [9]) require complex laboratory assessment [3], [10].