Flow cytometry data showed that the knockdown of SIPA1 in A172 cells arrested cell cycle progression in the G1 phase, which was further supported by the downregulation of cell cycle proteins Cyclin A2, Cyclin D1 and Cyclin E1 in glioma cells with SIPA1 knockdown (Figure 2E, Figure 2F). The gene discussed is CCND1; the disease is central nervous system cancer.