MYC and systemic lupus erythematosus: In agreement with these findings, suppressing c-Myc signaling in either CPG-DNA-treated B cells or IL-10+ B cells purified from blood of SLE patients efficiently decreased glycolysis (Fig. 5b, c and Supplementary Fig. 5h), as well as the subsequent inflammatory response and functional Breg cell generation (Fig. 5d and Supplementary Fig. 5i).