CD69 and systemic lupus erythematosus: In line with this, CD69+/hi B cells, as well as IL-10+ B cells, purified from SLE patients showed a similar expression pattern of glycolytic enzymes (Fig. 4f and Supplementary Fig. 4d), and these cells cultured ex vivo produced significantly more lactate (Fig. 4g) and displayed a greater capacity to incorporate the fluorescent glucose analog 2-(N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl] amino)−2-deoxyglucose (2-NBDG) (Fig. 4h and Supplementary Fig. 4e).