MYC and systemic lupus erythematosus: Functional Breg cells triggered by SLE pathological factors (e.g., CPG-DNA) display a previously unrecognized CD24intCD27−CD38−CD69+/hi phenotype and simultaneously produce high amounts of inflammatory mediators, and this process is dominated by MAPK/ERK/P38 signal-elicited sequential oncogenic c-Myc upregulation and enhanced glycolysis.