We were also unable to evaluate the potential mediating role of CRP and leptin in the obesity-breast cancer association due 1) to the lack of statistically significant association between BMI or WC and premenopausal breast cancer in our study population and 2) to the lack of statistically significant association between CRP or leptin levels and postmenopausal breast cancer risk after BMI adjustment. The gene discussed is LEP; the disease is breast carcinoma.