Indeed, 3p‐125b‐ASO‐loaded RBCEVs substantially induced apoptosis with TUNEL positive cells concentrated in the tumour bulk but not in the stroma as determined by TUNEL staining of the tumour sections, suggesting that miR‐125b knockdown and RIG‐I activation contribute to the tumoricidal activity mediated by 3p‐125b‐ASO (Figure 5h‐i). Here, RIGI is linked to neoplasm.