The first case was a 77-year-old immunosuppressed individual with B cell chronic lymphocytic leukemia who exhibited increased levels of the cytokines, interleukin (IL)1β, 6, 8, 10, interferon gamma (IFN)-γ and tumor necrosis factor (TNF)-α [13]. The gene discussed is TNF; the disease is B-cell chronic lymphocytic leukemia.