The same type of analysis in the dataset of exclusively upregulated mRNAs upon promastigote infection (i.e. PRO only UP) identified GO categories related to Apoptosis regulation (i.e. Bnip3, Cd274, Gclm), Hydrogen peroxide metabolism (Cat, Prdx1, Prdx6, Txnrd1), Response to protozoan (Cd40, Gbp2, Gbp3, Slc11a1), and Response to type I IFN (Ifit1, Ifit2, Igtp, Irgm1, Mnda) (Fig. 5A, middle panel, and Table S2). Here, IRGM is linked to infection.